Title : Associations between proteinuria severity and pregnancy outcomes in patients with preeclampsia
Abstract:
The kidneys are frequently affected in pregnant women with preeclampsia. We aimed to evaluate whether proteinuria could serve as a predictor for adverse pregnancy outcomes.
Methods: Clinical data from 151 pregnant women with preeclampsia diagnosed between March 2022 and July 2023 at >>> hospital were retrospectively collected and analyzed. Patients were divided into 3 groups based on the amount of 24-hour proteinuria: no proteinuria group (<0.3g/24h, n=37), mild to moderate proteinuria group (0.3-3.5g/24h, n=72) and massive proteinuria group (>3.5g/24h, n=42). Adverse pregnancy outcomes assessed included low birth weight, intrauterine growth restriction, transfer to the neonatal intensive care unit, and maternal mortality.
Results: The 3 groups showed no significant differences in terms of demographics and socioeconomic status. The massive proteinuria group presented with preeclampsia at an earlier gestational week than the no proteinuria group and the mild to moderate proteinuria group (P<0.001). The 3 groups showed no statistical significance with regard to eclampsia rate (7/42 vs 10/72 vs 4/37, P=0.75) and maternal mortality rate (1/42 vs 0/72 vs 0/37, P=0.27). However, the rates of low birth weight (23/42 vs 13/72 vs 3/37, P<0.0.001), intrauterine growth restriction (17/42 vs 15/72 vs 6/37, P=0.02), and transfer to the neonatal intensive care unit (26/42 vs 19/72 vs 8/37, P<0.001) were significantly higher in the massive proteinuria group compared to the no proteinuria group and the mild to moderate proteinuria group.
Conclusion: A higher proteinuria is associated with adverse pregnancy outcomes of low birth weight, intrauterine growth restriction, and transfer to the neonatal intensive care unit in pregnant women with eclampsia.
