Title : KLIC score for predicting unfavorable outcomes following hip replacement early acute prosthetic joint infections
Abstract:
Previous studies have reported conflicting results with regard to the predictive significance of the Kidney, Liver, Index surgery, Cemented prosthesis, and C-reactive protein value (KLIC) score for treatment responses. In this study, we aimed to explore the significance of KLIC score for predicting unfavorable outcomes in patients with early acute prosthetic joint infections.
Methods: We prospectively collected data from 64 patients with early acute prosthetic joint infections following hip replacement from a single center during March 2020 and December 2023. The primary endpoint is success or failure of the Debridement, antibiotic agents, and implant retention treatment. Treatment failure was defined as all-cause mortality, unscheduled surgery or prescription with long-term suppressive antibiotics at day 60.
Results: Univariate analysis showed that the a higher KLIC score was associated increased risk for treatment failure (OR=1.32 [95% CI 1.02-1.87], P=0.04). The area under the receiver-operaing characteristic curve for predicting treatment failure was 0.59 (95% CI 0.53-0.68). The predictive significance of the KLIC score disappeared (OR=1.03, 95% CI 0.72-1.34, P=0.53) in the fully adjusted regression model.
Conclusion: The KLIC score has limited efficacy for predicting treatment failure for early acute prosthetic joint infections in patients with hip replacement.
