Title : Multidisciplinary management of complex skull base pathologies whats in store for the future
Abstract:
Management of skull base pathologies remains a highly technical and multidisciplinary endeavor. These conditions are often rare, complex, and anatomically challenging, with limited high-quality, prospective studies available to guide evidence-based treatment. This scarcity of robust data, combined with the nuanced nature of each pathology, contributes to significant variability in clinical decision-making and outcomes across institutions.
To address these limitations and foster collaboration across specialties, the Registry of Adenomas of the Pituitary and Related Disorders (RAPID) was established as the first multispecialty, multi-institutional, prospective registry focused on the management of skull base pathologies. Currently, the registry includes 24 high-volume academic centers across the United States, bringing together expertise from neurosurgery, endocrinology, otolaryngology, radiation oncology, and neuro-ophthalmology. Its goal is to harmonize data collection, support longitudinal outcome tracking, and facilitate large-scale, collaborative research efforts.
To date, over a dozen studies utilizing RAPID data have addressed management strategies and outcomes in patients with Cushing’s disease and craniopharyngiomas, providing valuable insights into surgical approaches, perioperative management, and long-term endocrinologic and neurologic outcomes. Ongoing efforts aim to expand the scope of the registry to include additional skull base pathologies such as other functional and non-functioning pituitary adenomas
RAPID represents a major step toward addressing these gaps, offering a framework for collaboration and evidence generation that will ultimately improve patient care and outcomes.
