Children present unique physiological, psychological, and pharmacological considerations that require a highly specialized anesthetic approach. Pediatric anesthesia and sedation encompasses strategies that prioritize safety, comfort, and developmental sensitivity. From airway management in neonates to dosage calculations in adolescents, every step must be finely calibrated. Non-pharmacologic techniques, including parental presence and distraction methods, often complement pharmacological sedation to minimize anxiety and trauma. Technological advances like depth-of-anesthesia monitors adapted for children and age-specific ventilatory settings support greater intraoperative precision. Anesthetic agents with rapid onset and clearance profiles are preferred to allow smooth, fast recoveries. Additionally, growing emphasis on neurodevelopmental outcomes is prompting research into the long-term effects of sedatives on young brains. The evolving landscape of pediatric care demands anesthesia protocols that are as dynamic and individualized as the patients themselves.