Precision drug delivery has taken center stage in anesthetic practice with the use of Total Intravenous Anesthesia (TIVA) and Target-Controlled Infusion systems. By relying solely on intravenous agents, clinicians gain tighter control over sedation levels, reduce environmental exposure to volatile agents, and improve recovery profiles. Target-controlled infusion allows real-time dosing adjustments based on pharmacokinetic models, minimizing drug accumulation and promoting stable anesthetic depth. This approach proves especially useful in neurosurgical, pediatric, and outpatient procedures, where rapid emergence and hemodynamic stability are essential. With fewer postoperative complications such as nausea and cognitive dysfunction, TIVA offers a patient-friendly alternative. As monitoring devices and modeling algorithms become increasingly advanced, this technique continues to redefine the standards of individualized anesthetic care, blending clinical precision with safer outcomes.