Hemispherectomy is a complex surgical procedure involving the removal, disconnection, or functional isolation of one hemisphere of the brain. This intricate operation is typically conducted to alleviate severe and intractable epilepsy or to manage certain brain disorders. It involves disconnecting or removing a significant portion of the affected hemisphere, either partially or entirely. The surgery is considered as a last resort when other treatments have failed to control epileptic seizures or when there's severe brain damage. By isolating or removing the affected hemisphere, the aim is to prevent the spread of abnormal electrical activity that triggers seizures. Remarkably, the brain can adapt after a hemispherectomy, redistributing functions to the remaining hemisphere, especially when performed in young children whose brains are more plastic. Despite its effectiveness in controlling seizures, hemispherectomy is a highly intricate and risky procedure, carrying potential risks such as bleeding, infection, and cognitive deficits. Post-surgery, patients often require extensive rehabilitation to relearn certain skills and adjust to any functional changes resulting from the surgery. However, for some individuals, hemispherectomy can significantly improve their quality of life by reducing or eliminating debilitating seizures.